Doc Martin is set to return for one final series.
ITV confirmed that the popular show will start filming its 10th series in spring 2021, which will see the programme come to an end. It will then air later in the year.
Martin Clunes, who plays the lead role, and producer Philippa Braithwaite said: "We have loved making nine series of Doc Martin.
"When we launched the series in 2004 we could never have imagined how much our loyal viewers would take to the grumpy Doc like they have.
"The series has avid fans both in the UK and throughout the world and we are thrilled that Doc Martin has topped the ratings every time.
"However, after sixteen years we now feel that the time has come to say goodbye to Portwenn.
"We will be making the tenth and final series in 2021 and we are very much looking forward to returning to Cornwall to film it."
Polly Hill, ITV's head of drama, also paid tribute to the show, adding: "I just want to thank Martin and Philippa and everyone involved in Doc Martin, because it's a brilliant, beautifully made series that has delighted audiences for many years.
"I am pleased that we are making series 10, and sad this will be the last, but respect their decision to bring it to a close."
The show focuses on surgeon Dr Martin Ellingham who develops a fear of blood. After giving up practising, he moves to Cornwall where he becomes the sole GP in Portwenn and learns all about the local residents despite his grumpy nature.
As part of his General Medical Council scrutiny, Martin was assessed by surgeon Bernard Newton – and failed. Knowing that he'd be struck off, he resigned from his post – only for his wife Louisa to then announce she's pregnant.
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