Elated crowds thronged Tahrir Square and let loose fireworks into the night sky as they celebrated what they say is a second revolution.
One young protester told Sky News: "I feel proud, I feel happy I feel relieved that Egypt has changed a regime, a very fascist regime, to a multi-party regime, hopefully a democratic one."
In numbers rivalling those that saw off Hosni Mubarak two and a half years ago, protesters gathered all day as they have since last week, in Cairo, Alexandria, Suez and other towns.
Even among those who voted for Mr Morsi, there was an impatience to see him go.
Farmer Mansour told Sky News he bitterly regrets helping to put him in power because, he said, life has only got worse.
He said: "There's no gas to make our machines work, and all the plants die, what can people do, kids have no milk, no medicine, nothing."
Protesters concede Mr Morsi was voted president in elections, but accuse him of hijacking their revolution for his own ends.
They hope their revolutionary encore gives Egypt a second chance. But there were many expressing fear about the consequences, worried the Muslim Brotherhood will now take violent revenge.
There was a profound and surreal sense of deja vu about the events in Cairo to those of us who witnessed the first revolution.
But this is different. Instead of removing a dictator, the people and the military have deposed an elected president.
Egypt remains divided and its revolution in crisis, and violence seems likely.