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Former soap stars Tilly Keeper, Dario Coates, and Eve Austin are to star in 'You'.
The ex-'EastEnders' actress - who played Louise Mitchell in the BBC One soap from 2016 to 2020 - is among the British cast members who will appear alongside lead actor Penn Badgley, who plays serial killer Joe Goldberg, in the fourth series of the Netflix psychological thriller.
A TV insider said: "This will come as a huge surprise to the millions of fans of the show around the world, who got used to the first three seasons being based in various locations in the US.
"The last thing they would have expected was for the next outing to move lock, stock and barrel across the Atlantic and feature a largely British cast."
The drama's new series will also be filmed in the UK.
The insider added to The Sun newspaper's TV Biz column: "The producers wanted to provide a fresh take on the show, though Joe will no doubt be going back to his dark deeds when he arrives in London."
Dario is best known for portraying Kym Marsh's character Michelle Connor's son Alex Neeson, who was later played by James Burrows and was known as Ali.
Eve starred in two 'Emmerdale' episodes as Tabitha Taylor-Rudd, the daughter of Rebecca White's (Emily Head) friend Jools Taylor-Rudd (Charlotte Hunter).
As well as a host of soap stars, former 'Downton Abbey' actor Ed Speleers - who played Jimmy Kent in the period drama - and 'Gotham' actor Sean Pertwee are also set to appear in the show.
Since departing 'EastEnders', Tilly has gone on to appear in BBC Three TV film 'Make Me Famous' - which was created and written by Reggie Yates and starred Amanda Abbington, Nina Sosanya, and Emma Rigby - among other projects.