The TV chef opened up on the health nightmare Jools has been living with and said they had desperately been seeking help at Harley Street clinics, but that she was finding it "deeply scary".
Speaking to The Mail's Weekend magazine, Jamie, 47, said: "She's had bad COVID and long COVID so she's been really affected by it, sadly. She's ok, but still not what she wants to be.
"It's been two years. She finds it deeply scary. We're all over Harley Street like a rash, but no-one really knows anything. The data on long COVID is still piling in. She's been an absolute superstar."
The couple, who have been together since they were 18, have five children together ranging in age from 20 to five.
Jamie admitted that he'd "found teenage girls very hard" with his daughters Poppy, Daisy and Petal now aged 20, 19 and 13, while sons Buddy and River are 11 and five.
Saying that he missed getting hugs from his children as they got older, he added: "You never get the kid back after 13, they completely change. That took a while to get over. So I've struggled with the teenage years."
He also added that he thought his daughters had a tougher time at university because of having a famous dad, saying that they were "judged" and the subject of "banter" as soon as other students realised who they were.
The chef, who is known for campaigning for better quality school meals and support for children living in poverty, admitted that his new cookbook One: Simple One-Pan Wonders was "a middle-class cookbook for Middle England" and not intended to help struggling families with the cost of living crisis, saying people on universal credit "ain't buying this".
Watch: Jamie Oliver stages obesity protest outside of Downing Street