HBO Max dropped the first official trailer for the series on Tuesday, showing Cuoco as a flight attendant who finds herself in deep trouble after engaging in a personal relationship with a passenger.
In the trailer, Cassandra (Cuoco) wakes up in a hotel room to find her date dead in bed next to her. Further complicating the problem is the fact that she can't remember anything about the night before.
"The whole night is just flickers," she says. "I can't remember anything about it."
But as Cassandra scrambles to put the pieces together, the police are also hot on her trail.
"The flight attendant, she knows more than she's saying," one cop says.
The series, based on 2018 novel of the same name by Chris Bojalian, premieres with three episodes on Nov. 26, followed by two new episodes on Dec. 3, two episodes on Dec. 10, and the finale episode on Dec. 17.
The thriller also stars Michiel Huisman, Rosie Perez, Zosia Mamet, T.R. Knight, Colin Woodell, Merle Dandridge and more.
Cuoco, 34, previously told PEOPLE that she wanted to delve into a dramatic project after 12 years of starring on Big Bang Theory.
"I wanted to try something different, especially more of a dramatic role, which I don’t think anyone thinks I can do, and I know that I can, so I’m really excited about that," she said. "It’s been a whole new experience experiencing a show not just as an actor."
After filming on the show wrapped, Cuoco and Mamet, 32, commemorated their time on the series together with matching tattoos.
Cuoco shared the premiere date and poster for the show on Instagram Monday, writing in the caption, "✈️ START STREAMING THANKSGIVING DAY ✈️ @hbomax @flightattendantonmax #theflightattendant 🥂 🔪 🐰 (Thank you to the amazing team behind the making of this poster! @jamiemakeup @clarissanya @bradgoreski @daniela_viviana @catmthomas ) 📸 by the brilliant @ninomunoz."