The Good Morning Britain presenter’s husband was placed in a medically induced coma and spent more than a year in hospital after falling ill with the coronavirus early in 2020, and now needs round the clock care.
He returned to hospital this summer after falling ill with sepsis and Garraway has now shared that he is unwell again.
Writing in The Sun, she said: “Derek is back in hospital after developing sepsis that again threatened his life and we are again fighting to get him home.
“But I remain constantly inspired by those around him – not just for their expertise but for their loving care.”
Draper first fell ill in March 2020 and he returned home to Garraway and their two children — son Billy, 13, and daughter Darcey, 16 — in April 2021.
Draper previously had sepsis in the summer of 2022 after taking an 'unexpected and frightening turn for the worse' which led to another spell in hospital 'fighting for his life'.
TV star Garraway, 55, has kept fans updated on Draper's progress and last year she won a National Television Award for her documentary about his illness, Kate Garraway: Finding Derek.
She is nominated again this year for her follow up programme, Caring For Derek.
The presenter recently said that Draper, 55, remains "very damaged".
Opening up during an appearance on DNA Journey, she said: "With Derek, he got very sick very early on in the pandemic and has remained very damaged.
"That is quite well documented because for a lot of people, he has come to symbolise the fight that goes on."
Garraway and former political advisor Draper have been married since 2005.
Watch: Kate Garraway reflects on Derek Draper's difficult recovery from COVID