The US singer-songwriter will perform at London's iconic Hyde Park on the festival's closing night, Sunday, 9 July.
Take That, Pink and K-pop superstars Blackpink are also on this year's bill, as BST celebrates its 10th anniversary.
Del Rey's show will mark her first London concert since 2017. Here's everything you need to know about the long-awaited show.
How to buy Lana Del Rey tickets
It will be her second UK festival set of the summer, following a slot at Glastonbury on Saturday, 24 June.
Her setlist is likely to include some of her biggest hits, including Born to Die, West Coast and Summertime Sadness, as well as newer material.
The Brit Award-winning pop star recently topped UK charts with her latest album, Did You Know That There's a Tunnel Under Ocean Blvd.
It became her sixth UK number-one album, drawing her level with acts such as Arctic Monkeys, Radiohead and Blur, and is the fastest-selling vinyl release of 2023 so far.
The 16-track LP spawned singles including the gospel-infused The Grants and the folk-trap song A&W.
Del Rey, whose real name is Elizabeth Grant, rose to fame in 2011 with the release of her debut single, Video Games, a haunting ballad which became a viral hit.
Read more: The best music festivals of 2023
More than a decade later, she is one of pop's biggest stars and has collaborated with the likes of Taylor Swift, The Weeknd, Stevie Nicks, Ariana Grande and Miley Cyrus.
Last month, she was honoured with the Visionary Award at the Billboard Women in Music Awards.
In her acceptance speech, she praised fellow female stars Olivia Rodrigo and SZA, and addressed the criticism she faced earlier in her career.
Watch: Lana Del Rey reportedly engaged