Parts of major Tube lines including the Circle, District, Hammersmith and City and Metropolitan lines will be closed between Good Friday (April 14) and Easter Monday (April 17), Transport for London have revealed.
The entire Victoria line will be shut off from 3am on Easter Sunday until Tuesday April 18.
Services will be replaced by buses.
Elsewhere, Whitechapel station will be completely closed throughout the weekend.
Overground services will be cancelled between several major travel hubs while Southeastern Rail services will not stop at a number of central London stations.
No Circle line service between Hammersmith and Aldgate via King's Cross.
No Hammersmith & City line service between Liverpool Street and Barking.
No District line service between Aldgate East and West Ham.
No Metropolitan line services between Wembley Park and Northwood/Uxbridge.
No Victoria line service on Easter Sunday and Monday.
Replacement bus services will run between: Tower Hill - Aldgate / Aldgate East - Whitechapel - Stepney Green - Mile End - Bow Road - Bromley-by-Bow - Canning Town
Rayners Lane - North Harrow - West Harrow - Harrow-on-the-Hill - Northwick Park - Preston Road - Kenton (for the Bakerloo line) - Wembley Park
Northwood - Northwood Hills - Pinner - North Harrow - West Harrow - Harrow on the Hill - Wembley Park
Walthamstow Central - Blackhorse Road - Tottenham Hale - Seven Sisters - Manor House - Finsbury Park
Seven Sisters - Manor House - Finsbury Park - Holloway Road (northbound only) - Highbury & Islington – Angel
Victoria - Pimlico - Vauxhall - Stockwell – Brixton
Extra Piccadilly line trains will run between Rayners Lane and Uxbridge
No service between Camden Road and Stratford
No service between Romford and Upminster
No service between Highbury & Islington and Shadwell on Easter Sunday and Monday
No service between Surrey Quays and New Cross on Easter Sunday and Monday
Replacement buses will run between: Camden Road - Holloway Road (for Caledonian Road & Barnsbury) - Highbury & Islington - Canonbury - Dalston Junction (for Dalston Kingsland) - Hackey Central - Homerton - Hackney Wick – Stratford.
Dalston Kingsland - Dalston Junction - Haggerston - Hoxton - Shoreditch High Street - Whitechapel – Shadwell
No service between Stratford and Romford
No service between Newbury Park and Shenfield
No service between Bow Church and Stratford
No trains will run from Cannon Street, Deptford, Greenwich, Maze Hill and Westcombe Park.
No trains will run from Charing Cross Waterloo East, London Bridge, Cannon Street, Deptford, Greenwich, Maze Hill and Westcombe Park on Good Friday and Easter Saturday.
A rail replacement service will run between New Cross and Charlton calling at Deptford, Greenwich, Maze Hill and Westcombe Park.