Ronaldo heads back to Manchester amid accusations he sexually assaulted a woman in the United States in 2009 - an accusation the former Old Trafford forward strenuously denies.
The 33-year-old Portugal international is available after serving a one-match suspension following a red card against Valencia, and Mourinho's defence - out of sorts so far this season - will be tasked with stopping last season's top scorer in the Champions League.
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TV, online and live stream coverage
You can follow all the action on Standard Sport's LIVE match blog with James Robson at Old Trafford.
General sale tickets are now sold out, but Manchester United are still offering hospitality packages. Click here for more info on the club's website.
Betting tips via Betfair | UK users only | Subject to change
- Man Utd to win 1-0: 17/2
- Juventus to win 3-1: 14/1
- 1-1 draw: 5/1
- Under 1.5 goals: 11/5
Click here to find the latest match odds and place a bet.
Head to head
The two sides have met 12 times in Uefa competitions, each winning five games and sharing two draws.
The last time they met in the Champions League was back in 2002-03, with United beating Juve 2-1 at home and 3-0 away in the second group stage.
United fans will also fondly remember the dramatic semi-final comeback in over Juve en route to lifting the 1998-99 Champions League trophy to complete the Treble.