Ireland visit Twickenham this afternoon aiming to complete only the third Grand Slam in their history.
England's hopes of winning an historic third straight Six Nations crown were ended by France last week. The Red Rose lost 22-16 in Paris, falling to back-to-back defeats for the first time since Eddie Jones took the reins in 2015.
And England will be keen to show successive defeats to Scotland and France represent only a brief blip as Jones tries to form a team capable of challenging for the World Cup in 2019.
Added to that will be the incentive of ending Ireland's Grand Slam bid at the final hurdle.
Before England host Ireland at 2.45pm, Italy welcome Scotland at 12.30pm. Wales vs France concludes this year's Championship at 5pm.
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|Anthony Watson||15||Rob Kearney|
|Jonny May||14||Keith Earls|
|Jonathan Joseph||13||Garry Ringrose|
|Ben Te’o||12||Bundee Aki|
|Elliot Daly||11||Jacob Stockdale|
|Owen Farrell||10||Johnny Sexton|
|Richard Wigglesworth||9||Conor Murray|
|Mako Vunipola||1||Cian Healy|
|Dylan Hartley (capt)||2||Rory Best (capt)|
|Kyle Sinckler||3||Tadhg Furlong|
|Maro Itoje||4||James Ryan|
|George Kruis||5||Iain Henderson|
|Chris Robshaw||6||Peter O’Mahony|
|James Haskell||7||Dan Leavy|
|Sam Simmonds||8||CJ Stander|
Betting odds (provided by betfair)