Graham Potter’s men have had a tough recent run, facing the likes of Liverpool and Manchester City, and will aim to get back to wining ways to end the season on a high.
They perhaps still need a result to be absolutely clear of the drop, but realistically are clear of the biggest battle at the bottom now.
Saints showed great tenacity and spirit to take a late point off Manchester United last time out and will still be looking further up the table.
Here’s everything you need to know ahead of the game.
When is it and what time is kick-off?
The match will begin at 8:15pm on Thursday 16 July at St. Mary’s.
How can I watch it online and on TV?
The match will be broadcast live on BT Sport 2 and BT Sport Extra 2. Coverage starts at 8pm.
Southampton: McCarthy, Smallbone, Vestergaard, Bednarek, Vokins, Hojberg, Romeu, Ward-Prowse, Redmond, Ings, Obafemi
Brighton: Ryan, Lamptey, Dunk, Webster, Burn, March, Propper, Stephens, Trossard, Maupay, Murray
What are the odds?
Southampton – 13/10
Draw – 5/2
Brighton – 5/2
Both teams will want to get on the ball and control possession, which could lead to an open match with counter-attacks aplenty and chances at both ends. Saints are more clinical, so they win.
Southampton 2-1 Brighton