Spitting Image creator Roger Law has insisted the show's revival will ridicule political figures from both the right and left.
It comes as Conservative politicians have featured heavily in previews of the satirical puppets, including in the recently launched trailer.
However, Law insists people on both sides of the political spectrum will be lampooned and that it would be "no fun" in just sticking it to the right.
"There’s lots of ammunition to throw at the other side as well. You go for them all," he explained on The Andrew Marr Show.
The show began in 1984 while Margaret Thatcher was Prime Minister, with her and her Cabinet being routinely mocked via their puppet alter egos. However, Law thinks there was a predictability to her actions compared with the current Conservative government.
“When we started Spitting Image, everything was in turmoil. There were riots in the streets… and of course you had Thatcher.
“You start looking on Thatcher with nostalgia because at least you knew what she was about and what she was going to do, if you thought about it. Boris and the boys, you’ve got no idea, and the ideology is absolutely nuts,” Law said.
The original series took aim at Thatcher's Opposition, including Labour politicians Neil Kinnock, Tony Benn and Michael Foot.
Read more: More Spitting Image puppets unveiled
Overseas political figures Donald Trump, Bernie Sanders and Vladimir Putin will be parodied in the reboot alongside stars such as RuPaul, Kim Kardashian, Elon Musk and Adele.
New episodes of the series are set to land on streaming service BritBox on Saturday 3 October.
Watch: Boris Johnson and Donald Trump star in the Spitting Image trailer