Richarlison is banned for the Premier League opener after throwing a flare into the stands while celebrating a goal in his latter days at Everton.
Ivan Perisic was labelled a doubt by the Spurs boss while returning from a calf issue suffered in his final game for Inter Milan, which could still allow him to make his debut off the bench.
Likewise, Yves Bissouma is not risked from the start having tweaked his hamstring. The new midfielder also missed a portion of pre-season due to Covid-19, but is on the bench.
Clement Lenglet, Fraser Forster and Djed Spence are also kept on the bench for the visit of the Saints, Emerson Royal being favoured over Spence at right wing-back with Matt Doherty also a sub on his return from knee surgery.
Oliver Skipp is Tottenham’s final absentee due to a hairline fracture to the heel.
Tottenham starting XI: Lloris, Romero, Dier, Davies, Emerson, Hojbjerg, Bentancur, Sessegnon, Kulusevski, Son, Kane
Subs: Doherty, Sanchez, Gil, Perisic, Forster, Spence, Lucas Moura, Lenglet, Bissouma