It is just the Ukrainianâs second fight in the division, which was originally supposed to happen back in May, but is now happening amid the coronavius pandemic.
Victory here will keep alive the prospect of facing Anthony Joshua by protecting his status as the manadatory challenger for the Britonâs WBO world heavyweight title.
It is probably Chisoraâs last chance to position himself in the mix for world honours with the lengthy queue to face both Joshua for his WBO, WBA and IBF titles, as well as Tyson Fury, who owns the WBC title.
Hereâs everything you need to know about the fight.
When and where is it?
The fight is on Saturday, 31 October, at Wembley Arena in London, coverage of the card begins at 7pm.
The exact start time for the fight is notoriously difficult to predict, but we can expect the ring walks some time after 10pm, though the outcome of the fights on the undercard will play a factor in exactly when the first bell rings.
How can I watch it?
You can watch the game on Sky Sports Box Office at a cost of Â£19.95 and purchase the fight here.
You do not need to be a Sky customer to purchase the fight, just sign up for a Sky Sports Box Office account and purchase the fight here. Ensure you have a working broadband connection. The fight can then be streamed live on PC, Mac, NOW TV Box, NOW TV Smart Stick, iPhone, iPad, Android phone and tablet.
Repeats are at 11pm on Sunday 1 November and 9am on Monday 2 November.
Who is fighting?
Main event - heavyweight: Oleksandr Usyk (17-0) vs Derek Chisora (32-9)
Lightweight: Lee Selby (28-2) vs George Kambosos Jnr (18-0)
Cruiserweight (vacant EBU European cruiserweight title): Tommy McCarthy (16-2) vs Bilal Laggoune (25-1-2)
Middleweight (vacant World Boxing Organisation world female middleweight title): Savannah Marshall (8-0) vs Hannah Rankin (9-4)
Super bantamweight (vacant Commonwealth (British Empire) female super bantamweight title): Amy Timlin (4-0) vs Carly Skelly (3-0)
Heavyweight: David Allen (18-5-2) vs Christopher Lovejoy (19-0)
Bantamweight: Ukashir Farooq (13-1) vs Martin Tecuapetla (15-12-4)
Usyk by KO/TKO: 11/10
Usyk by decision: 5/4
Chisora by KO/TKO: 11 / 2
Chisora by decision: 16/1