After two experimental games against Wales, England have gone full-strength against the Irish as George Ford, Owen Farrell and Manu Tuilagi line-up in a new-look midfield while Tom Curry and Sam Underhill finally get a run-out together in the back-row, two weeks later than planned. However, England have suffered an injury blow for the third week in succession as replacement Jonathan Joseph has been ruled out with 'muscle soreness', meaning Joe Marchant has been drafted in to take his place on the bench.
Ireland meanwhile have also gone all-out for the clash with a side that is remarkably similar to the one that clinched the 2018 Grand Slam at Twickenham, although with Johnny Sexton and Joey Carbery injured Ross Bryne is trusted at fly-half by Joe Schmidt. Follow the live updates below.
When is it?
England vs Ireland takes place at Twickenham Stadium on Saturday 24 August.
What time does it start?
The match kicks off at 3pm.
England: Elliot Daly; Joe Cokanasiga, Manu Tuilagi, Owen Farrell, Jonny May; George Ford, Ben Youngs; Joe Marler, Jamie George, Kyle Sinckler; Maro Itoje, George Kruis; Tom Curry, Sam Underhill, Billy Vunipola.
Replacements: Luke Cowan-Dickie, Mako Vunipola, Dan Cole, Courtney Lawes, Mark Wilson, Willi Heinz, Piers Francis, Jonathan Joseph.
Ireland: Rob Kearney; Jordan Larmour, Garry Ringrose, Bundee Aki, Jacob Stockdale; Ross Byrne, Conor Murray; Cian Healy, Rory Best, Tadhg Furlong; Iain Henderson, Jean Kleyn; Peter O’Mahony, Josh van der Flier, CJ Stander.
Replacements: Sean Cronin, Jack McGrath, Andrew Porter, Devin Toner, Tadhg Beirne, Luke McGrath, Jack Carty, Andrew Conway.
England to win: 2/5
Ireland to win: 11/4
England by eight: Eddie Jones has thrown his players into the fire with a shortened training week, but that could have the desired effect in triggering a response to prove they are ready for the World Cup campaign. Given they are a match further into their World Cup preparations, England may just be able to catch Ireland cold.