The much-anticipated eighth series left many fans feeling underwhelmed and thousands signed a petition calling for all six of its episodes to be remade.
Daenerys Targaryen actress Clarke has admitted that the reaction “sucks”, but insisted the show’s cast and crew could not have pleased everyone.
She told Stellar magazine: “Everyone is going to have their own opinion and they’re fully entitled to them.
“It’s art and it’s to be dissected and taken on in whatever individual way you wish.
“And if you’re sad that the show is done and you’re sad because you enjoyed watching it, then that’s sad.
“It sucks this wasn’t the perfect ending that people were hoping for, but I truly believe we would never have made everyone happy,” she said.
The closing episodes of the hit series saw Clarke's character meet an untimely end, after becoming the mad ruler she had promised not to be.
A number of Clarke’s costars have already addressed the negative reaction with Jacob Anderson previously telling Standard Online: “Some people are going to love it and some people are going to hate it and that’s always going to be down to taste.
"So if somebody has a problem with it and they kind of tell me about... I don’t know what they expect me to do.”
Clarke also told Stellar how she felt after the show wrapped, adding: “It really was the greatest moment of my life, but there is an absolute freedom that Thrones has given me – a gift-wrapped present in a little bow saying, ‘You’re now financially secure enough to not have to panic, so what do you want to do?’.”
Later this year, she’ll star in the festive film, Last Christmas, alongside Crazy Rich Asians actor Henry Golding.
With additional reporting by Press Association