In the film, the property becomes home to Edward (played by Johnny Depp) after he moves in with the Boggs family.
The real house is located in Tampa Bay, Florida, in a suburban town called Lutz.
While the distinctive turquoise exterior has been painted over, fans of Edward Scissorhands will recognise both the interior and exterior of the residence, which was constructed in 1989, shortly before filming began.
Several of the interior features remain unchanged from the film, including kitchen cabinets and counters.
The 1,432-square-foot property features three bedrooms and two bathrooms and has had a total of two owners since the time of Edward Scissorhands.
The house is currently on sale for $224,000 (£171,600), although the estate agents have already seen an influx of offers from interested parties.
On Facebook, the listing for the house reads: “EDWARD SCISSORHANDS HOUSE FOR SALE!!! Many of the locals know about the home that was used for the movie Edward Scissorhands movie in the Carpenters Run neighborhood in Land O Lakes. Well, it’s now up for grabs!! Who wants it?!?!”
Released in 1990, Edward Scissorhands starred Depp as the Frankenstein-like creation of an elderly inventor, who is taken in by a suburban family and falls in love with their teenaged daughter Kim (Winona Ryder).