The 53-year-old presenter had been absent from the ITV programme since 20 February following the sudden passing of the SBTV founder at the age of 31.
Following weeks of mourning, Edwards gave her first interview about the loss of her son to co-panellist and close friend Coleen Nolan, which aired on Monday’s instalment of the daytime show.
However, Tuesday saw the presenter return to the live TV set and she took time to pay tribute to her late son by posting a video of herself singing backstage.
Edwards could be heard belting out Sia’s hit single 'Chandelier' in the clip which she captioned: "First show back @loosewomen with @ruthlangsford @coleen_nolan @kellebryan with bespoke liquorice jewellery and my corridor sessions today I dedicate to my baby Jamal who would love this cheeky cameo from the divine @thescript_danny#SelfBelief#loosewomen."
Fans immediately sent their love for the star, with one writing: "What a voice and what a woman."
Another supportive follower added: "It will be great to see you back Brenda, big step for you will be supporting you all the way!!"
During the show, Brenda spoke about parenthood while discussing how to support working mothers with creches and working from home structure with co-stars Ruth Langsford, Coleen Nolan and Kéllé Bryan.
Edwards — who is also mother to her daughter Tanisha, 22 — had been opening up to Nolan about her son’s final moment in the pair’s sit down interview the day before.
"The one thing I do want to say is I was with him and his sister was with us, we were all at home," she explained. "It was sudden and unexpected, he went into cardiac arrest and he passed with me holding his hand."
She continued: "I get a little bit of comfort knowing I was with him, but as much as it is comfort it's an image I'm never going to forget."
The TV star has since launched a trust to honour her son, called the Jamal Edwards Self Belief Trust.
Watch: Brenda Edwards Remembers Son Jamal In Loose Women Interview